Analysis of the severity of chronic obstructive pulmonary disease effect on the outcomes and quality of life of patients depressive disorder comorbidity

[I. M. Jelić]

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Simptomi depresije veoma često se javljaju kod pacijenata koji boluju od hronične opstruktivne bolesti pluća (HOBP). Varijabilnost u prevalenci u studijama ustanovljena je pomoću različitih kriterijuma, kao što su: stadijum bolesti, metode procene i višestruki dijagnostički kriterijumi za ocenu stanja HOBP-a i depresije. Ovo istraživanje sprovedeno je prema modelu kohortno-prospektivne studije praćenja ishoda lečenja komorbiditeta depresije antidepresivima u odnosu na stepen težine HOBP-a. Psihometrijske procene prisutne psihopatologije utvrđene su korišćenjem Hamiltonove skale za procenu stepena depresije i Upitnika za ispitivanje kvaliteta života i zadovoljstva životom na uzorku od 120 pacijenata. Rezultati istraživanja ukazali su na to da je prosečna starost ispitanika bila 48,71±7,49 godina, bez statistički značajnijih razlika između polova. Ukupno 47,5% ispitanika ima dispneju srednje teškog stepena, 35,8% dispneju blagog stepena i 13,3% dispneju teškog stepena, među kojima postoji jaka pozitivna korelacija stepena opstrukcije i težine dispneje. Pre početka lečenja depresije, 48,3% ispitanika imalo je umerenu depresiju, 38,3% depresiju blagog stepena i 13,3% tešku depresiju. Nakon uvođenja terapije antidepresivivima, došlo je do statistički značajnog poboljšanja depresivnog poremećaja, odnosno kod 91,3% ispitanika došlo je do smanjenja stepena depresije u pravcu blage depresivne epizode, a kod ispitanika sa teškom depresivnom epizodom došlo je do poboljšanja u smislu umerene depresije. Istraživanje je pokazalo da primena antidepresiva kod pacijenata sa HOBP-om i komorbiditetom depresije dovodi do smanjenja stepena depresije, a time i do sveobuhvatnog poboljšanja kvaliteta života pacijenata sa HOBP-om.

Тhe symptoms of depression occur very often in patients suffering from chronic obstructive pulmonary disease (COPD). Variability in prevalence across studies may exist based on different criteria, such as phase of disease, assessment methods, and different diagnostic criteria for both COPD and depression. This research is a prospective-cohort study that monitors the outcome of comorbid depression treatment with antidepressants in relation to the severity of COPD. Psychometric assessments of the present psychopathology were determined using the Hamilton Scale for Depression and the Quality of Life Enjoyment and Satisfaction Questionnaire within the sample of 120 patients. The results of the research indicated that the average age of the respondents was 48.71±7.49 years, with no statistically significant difference between the sexes. A total of 47.5% respondents have medium dyspnea, 35.8% of them have mild dyspnea, and 13.3% have severe dyspnea, among which there is a strong positive correlation between the degree of obstruction and severity of dyspnea. Before starting treatment for depression, 48.3% of respondents had moderate depression, 38.3% mild depression and 13.3% severe depression After the introduction of antidepressant therapy, there is a statistically significant improvement in depressive disorder, in 91.3% of respondents who had mild depression at the beginning of the study depressive symptoms have disappeared; almost all subjects with moderate depression now have mild depression. The research proved that implementing antidepressants in patients with COPD and comorbid depression leads to depression improvement, and therefore overall improvement of life satisfaction of patients suffering from COPD.

HOBP, depresija, kohortna studija, kvalitet života

COPD, depression, cohort study, quality of life

616.89:612.24(043.3)

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