Characteristics of patients with dysfunctional perimenopausal bleeding

[R. R. Ivanović]

73 листа

Uvod: Kod žena u perimenopauzi relativno često se sreće problem disfunkcionalnog produženog perimenopauzalnog krvarenja (DPPMK). Naš cilj je bio da se utvrde karakteristike pacijentkinja u perimenopauzi koje su povezane sa nastankom DPPMK. Materijal i metod: Ovo je bila prospektivna, klinička opservaciona studija slučajkontrola. U studiju su uključene žene koje su se nalazile u perimenopauzalnom periodu života. Ispitanice su podjeljene u dvije grupe: prvu grupu su činile žene sa DPPMK, dok su drugu, kontrolnu grupu činile žene bez DPPMK. Ženama koje su učestvovale u ovom istraživanju mjerene su serumske koncentracije hormona štitaste žlijezde, hormona hipofize i polnih hormona. Stepen depresivnosti procjenjivan je pomoću Hamiltonova skala depresivnosti. Podaci o vrijednostima velikog broja nezavisnih i zbunjujućih varijabli prikupljani su pomoću posebno osmišljenog upitnika i uvidom u medicinsku dokumentaciju žena. Statistička obrada podataka vršena je pomoću SPSS softverskog paketa. Rezultati: Faktori rizika koji doprinose pojavi DPPMK kod žena su starost, visoke vrijednosti BMI, konzumiranje alkohola i cigareta i upotreba lijekova za liječenje hroničnih oboljenja. Pacijentkinje sa DPPMK imale su značajno više koncentracije FSH, estradiola i prolaktina, a značajno niže koncentracije testosterona, progesterona i TSH. Takođe, među pacijentkinjama sa DPPMK bilo je značajno više onih sa simptomima blage i srednje teške depresije. Zaključak: Prilikom pregleda žena u perimenopauzi, ginekolozi trebaju da istaknu štetnost pušenja i upotrebe alkohola, kao i značaj liječenja gojaznosti i hipertenzije. Ključne reči: perimenopauza, disfunkcionalno uterusno krvarenje, faktori rizika.

Introduction: In perimenopausal women, the problem of dysfunctional prolonged perimenopausal bleeding (DPPB) is relatively common. Our aim was to determine the characteristics of perimenopausal patients that are associated with the onset of DPPB. Material and methods: This was a prospective, clinical observational case-control study. The study included women who were in the perimenopausal period of life. The women were divided into two groups: the first group was made up of women with DPPB, while the second, the control group, was made up of women without DPPB. The serum concentrations of thyroid hormones, pituitary hormones, and sex hormones were measured in the women who participated in this research. The degree of depression was assessed using the Hamilton Depression Scale. Data on the values of a large number of independent and confounding variables were collected using a specially designed questionnaire and an insight into the women's medical records. Statistical data processing was performed using the SPSS software package. Results: Risk factors that contribute to the occurrence of DPPB in women are age, high BMI values, alcohol and cigarette consumption, and the use of medications for the treatment of chronic diseases. Patients with DPPB had significantly higher concentrations of FSH, estradiol, and prolactin and significantly lower concentrations of testosterone, progesterone, and TSH. Also, among the patients with DPPB, there were significantly more of those with symptoms of mild and moderate depression. Conclusion: When examining perimenopausal women, gynecologists should emphasize the harm of smoking and alcohol use, as well as the importance of treating obesity and hypertension

perimenopauza, disfunkcionalno uterusno krvarenje, faktori rizika.

perimenopause, dysfunctional uterine bleeding, risk factors.

618 (043.3)

Ginekologija

Tekst