ǂThe ǂinfluence os Sneznik mineral water on microbiota, metabolic, biochemical and anthropometric parameters in patients with type 2 diabetes mellitus

[N. B. Jovičić]

107 listova

Uvod: s obzirom da je mineralna vode sa izvora „Snežnik-1/79“ još od početka 20. veka bila prepoznata za lečenje problema gastrointestinalnog trakta, glavna hipoteza ove studije je bila da njena upotreba može doprineti u otklanjanju konstipacije kod pacijenata sa dijabetes melitusom tipa 2. Cilj: ispitivanje uticaja mineralne, slabo kisele vode sa izvora „Snežnik-1/79“ na mikrobiotu, metaboličke, biohemijske i antropometrijske parametre kod pacijenata sa dijabetes melitusom tipa 2 (T2DM). Metode: studija je sprovedena na 60 ispitanika, pacijenata obolelih od T2DM koji su lečeni u Specijalnoj bolnici Merkur, Vrnjačka Banja. Po prijemu u bolnicu ispitanici su metodom slučajnog uzorka svrstani u 2 jednake grupe: 1. grupa: ispitanici koji su uz odgovarajuću terapiju uzimali i propisanu količinu mineralne vode sa izvora „Snežnik-1/79“ u trajanju od 3 nedelje; 2. grupa: ispitanici koji su uz odgovarajuću terapiju uzimali i propisanu količinu obične vode za piće iz vodovodnog sistema u trajanju od 3 nedelje. Na početku i na kraju studije mereni su sledeći parametri: antropometrijski parametri procena telesnog sastava, dnevnik dnevnih obroka, dnevnik praćenja crevnog pražnjenja, mikrobiotska analiza stolice, vrednosti HbA1C, glikemije i insulinemije (našte), lipidogram, jonogram, vrednosti arterijskog krvnog pritiska, markeri oksidacionog stresa i enzimi antioksidacione zaštite (superoksid dizmutazaSOD, katalaza-CAT i redukovani glutation-GSH). Rezultati: konzumiranje ispitivane vode bilo povezano sa pozitivnim promenama mikrobiote ovih pacijenata kao i redukcojom konstipacije. Osim toga, nakon upotrebe "Snežnik" vode došlo je do upadljivo niže produkcije pro-oksidanasa i istovremeno povećane mobilnosti svih merenih enzima antioksidacionog sistema zaštite.

Introduction: considering that the mineral water from the spring "Sneznik-1/79" has been recognized since the beginning of the 20th century for the treatment of gastrointestinal tract problems, the main hypothesis of this study was that its use can contribute in reduction of constipation in patients with diabetes mellitus type 2. Objective: estimation of the effects of mineral, weakly acidic water from the spring "Sneznik1/79" on microbiota, metabolic, biochemical and anthropometric parameters in patients with type 2 diabetes mellitus (T2DM). Methods: the study was conducted on 60 subjects, patients suffering from T2DM who were treated at the Merkur Special Hospital, Vrnjacka Banja. Upon admission to the hospital, the subjects were randomly divided into 2 equal groups: 1. group: subjects who, along with appropriate therapy, also took the prescribed amount of mineral water from the spring "Sneznik1/79" for 3 weeks; 2. group: subjects who, along with appropriate therapy, also took the prescribed amount of ordinary drinking water from the water supply system for 3 weeks. At the beginning and at the end of the study, the following parameters were measured: anthropometric parameters, body composition assessment, diary of daily meals, diary of intestinal emptying, microbiota analysis of stool, values of HbA1C, glycemia and insulinemia, lipidogram, ionogram, arterial blood pressure, oxidative stress markers and antioxidant protection enzymes (superoxide dismutase-SOD, catalase-CAT and reduced glutathione-GSH). Results: the consumption of the tested water was associated with positive changes in the microbiota of these patients as well as with the reduction of constipation. In addition, after the use of "Sneznik" water, there was a significantly lower production of pro-oxidants and at the same time an increased mobility of all measured enzymes of the antioxidant protection system.

mineralna voda, mikrobiota, glikemija, oksidacioni stres, dijabetes melitus tip 2

mineral water, microbiota, glycemia, oxidative stress, diabetes mellitus type 2

616.379-008.64:553.7(043.3)

Tekst