Structure and antimicrobial activity of copper(II), zinc(II) and silver(I) complexes with pyridine-containing ligands

[T. P. Andrejević]

139, [5] listova

U okviru ove doktorske disertacije, sintetisani su kompleksi bakra(II), cinka(II) i srebra(I) sa ligandima koji sadrže piridin kao potencijalni antimikrobni agensi. Sintetisani kompleksi su strukturno okarakterisani primenom spektroskopskih, elektrohemijskih i kristalografskih metoda. Ispitivana je njihova antimikrobna aktivnost na različitim bakterijskim i gljivičnim vrstama. Pored toga, ispitivana je i antiproliferativna aktivnost sintetisanih kompleksa na zdravoj ćelijskoj liniji fibroblasta pluća (MRC-5) u cilju određivanja njihove eventualne citotoksičnosti, to jest terapeutskog profila. Strukturne osobine i antimikrobna aktivnost sintetisanih kompleksa bakra(II), cinka(II) i srebra(I) su poređene sa odgovarajućim osobinama strukturno sličnih kompleksa, kao i sa lekovima koji se primenjuju u terapiji infekcija izazvananih mikroorganizmima. U prvom delu doktorske disertacije opisan je problem razvoja rezistentnosti mikroorganizama na klinički korišćene lekove, koji predstavljaju derivate organskih jedinjenja. Pored toga, prikazan je značaj jedinjenja na bazi jona metala, koja su još od davnih vremena pokazala efekte u terapiji infekcija izazvanih mikroorganizmima i drugih bolesti. Dat je pregled kompleksa bakra(II), cinka(II) i srebra(I) sa aromatičnim heterocikličnim ligandima koji sadrže donorski atom azota i koji su pokazali antimikrobnu aktivnost. U drugom delu disertacije, opisani su postupci za sintezu kompleksa bakra(II), cinka(II) i srebra(I), metode korišćene za njihovu strukturnu karakterizaciju, ispitivanje njihove antimikrobne aktivnosti, kao i za ispitivanje njihove reaktivnosti prema biološki značajnim molekulima. U trećem delu prikazani su rezultati spektroskopske karakterizacije i rendgenske strukturne analize sintetisanih kompleksa, rezultati ispitivanja njihove antimikrobne i citotoksične aktivnosti, kao i rezultati interakcija sintetisanih kompleksa sa biomolekulima.

In this doctoral dissertation, copper(II), zinc(II) and silver(I) complexes with pyridinecontaining ligands have been synthesized and evaluated as potential antimicrobial agents. The synthesized complexes were structurally characterized by spectroscopic, electrochemical, and crystallographic methods. Their antimicrobial activity was evaluated against different bacterial and fungal species. Besides that, antiproliferative activity of the synthesized complexes on the healthy human lung fibroblast cell line (MRC-5) has been studied to determine their potential cytotoxicity in order to determine their therapeutic profile. The structural properties and antimicrobial activity of the synthesized copper(II), zinc(II) and silver(I) complexes have been compared with the corresponding properties of the structurally similar complexes and clinically used antimicrobial agents. In the first part of the doctoral dissertation, development of the resistance of microorganisms to the clinically used drugs, which are derivatives of organic compounds, is described. Moreover, the importance of metal-based compounds, which have shown effectiveness in the treatment of infections caused by microorganisms and other diseases from ancient times, is also presented. An overview of the copper(II), zinc(II) and silver(I) complexes with aromatic nitrogen-containing heterocyclic ligands that have shown antimicrobial activity is given. In the second part of the doctoral dissertation, procedures for the synthesis of copper(II), zinc(II) and silver(I) complexes are described, as well as methods used for their structural characterization, antimicrobial evaluation and their reactivity towards biologically significant molecules. In the third part, the results of the spectroscopic and singlecrystal X-ray diffraction analysis of the synthesized copper(II), zinc(II) and silver(I) complexes have been presented, the results obtained by evaluation of their antimicrobial and cytotoxic activity, as well as the results of their interactions with biomolecules.

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