Title
Uticaj sastojaka energetskih napitaka na funkciju miokarda i oksidativni stres u izolovanom srcu i krvi pacova
Creator
Pušica, Irena, 1983- 33566567
Copyright date
2019
Object Links
Select license
Autorstvo-Nekomercijalno 3.0 Srbija (CC BY-NC 3.0)
License description
Dozvoljavate umnožavanje, distribuciju i javno saopštavanje dela, i prerade, ako se navede ime autora na način odredjen od strane autora ili davaoca licence. Ova licenca ne dozvoljava komercijalnu upotrebu dela. Osnovni opis Licence: http://creativecommons.org/licenses/by-nc/3.0/rs/deed.sr_LATN Sadržaj ugovora u celini: http://creativecommons.org/licenses/by-nc/3.0/rs/legalcode.sr-Latn
Language
Serbian
Cobiss-ID
Inventory ID
D-3306
Theses Type
Doktorska disertacija
description
Datum odbrane: 15.11.2019.
Other responsibilities
mentor
Đorđević, Dušica, 1982- 11532647
predsednik komisije
Živković, Vladimir, 1984- 12116071
član komisije
Zdravković, Vladimir, 1973- 11117927
član komisije
Radovanović, Dragan, 1975- 8357735
Academic Expertise
Medicinske nauke
University
Univerzitet u Kragujevcu
Faculty
Fakultet medicinskih nauka
Alternative title
The effect of energy drink ingredients on myocardial function and oxidative stress
in isolated heart and blood of rats
Publisher
Format
210 listova
Abstract (en)
Introduction. Energy drinks (EDs) are widely used by athletes as ergogenic agents. The aims of this study were to determine the acute, chronic and direct effects of Red Bull®, one of the most consumed EDs, on cardiodynamics and the parameters of oxidative stress in physically active and physically inactive rats.
Material and method. The study lasted 4 weeks. Rats were divided into 2 groups depending on
the consumption of Red Bull (3.75 ml/kg), and each group was divided into 2 subgroups,
depending on the physical activity. The trained rats were subjected to a swimming practice (1h per
day, 5 days a week). After sacrificing, the animals were sampled for venous blood to determine
the plasma redox status. Subsequently, the hearts were isolated and perfused by Langendorf
method of retrograde perfusion. The coronary flow and parameters of left ventricular function were
monitored: maximum rate of change of left ventricle pressure, minimum rate of change of left
ventricle pressure, systolic left ventricular pressure, diastolic left ventricular pressure, and heart
rate. The biomarkers of oxidative stress in the blood and effluent were determined by the
spectrophotometric methods: superoxide anion radical, hydrogen peroxide, index of lipid
peroxidation, nitrite monoxide in the form of nitrite, as well as the parameters of antioxidant
protection system: superoxide dismutase, catalase and reduced glutathione.Results. The negative effects of the acute, chronic and direct administration of the ED on cardiac
function were registered in untrained animals. In trained animals, the acute and chronic
consumption of the ED resulted in increasing the coronary flow and most cardiodynamic
parameters, while the direct administration of the ED resulted in decreasing rates of contractility
and relaxation, and was associated with the depression of cardiac function. In untrained animals,
the administration of the ED had a pro-oxidative effect in the coronary effluent (acute and direct
administration) as well as in blood (acute and chronic administration). In trained animals, the acute,
chronic and direct administration of the ED had a pro-oxidative potential in the coronary effluent,
whereas antioxidant activity was registered in the blood after the acute administration of the ED.
Conclusion. Our study contributes to the knowledge on the effects of EDs on cardiodynamics and
the redox status correlated with the exercise status.
Abstract (sr)
Uvod. Energetska pića (EP-a) se koriste u velikoj meri kao ergogena sredstva. Ciljevi ovog istraživanja bili su da se utvrde akutni, hronični i direktni efekti Red Bull®-a, jednog od EP-a koje se najviše konzumira, na kardiodinamiku i parametre oksidativnog stresa kod fizički aktivnih i fizički neaktivnih pacova.
Materijal i metod. Studija je trajala 4 nedelje. Pacovi su podeljeni u 2 grupe u zavisnosti od konzumacije Red Bull-a (3,75 ml/kg), a svaka grupa podeljena je u 2 podgrupe, u zavisnosti od fizičke aktivnosti. Trenirani pacovi su bili podvrgnuti treningu plivanja (1 čas dnevno, 5 dana u nedelji). Nakon žrtvovanja, životinjama je uzet uzorak venske krvi, radi određivanja redoks statusa u plazmi. Nakon toga, srca su izolovana i perfundovana metodom retrogradne perfuzije po Langendorfu. Praćeni su koronarni protok i parametri funkcije leve komore: maksimalna stopa promene pritiska u levoj
komori, minimalna stopa promene pritiska u levoj komori, sistolni pritisak leve
komore, dijastolni pritisak leve komore i srčana frekvenca. U uzorcima krvi i u
efluentu spektrofotometrijskim metodama određivani su biomarkeri oksidativnog
stresa: superoksid anjon radikal, vodonik peroksid, indeks lipidne peroksidacije, azot
monoksid u formi nitrita, kao i parametri antioksidativnog sistema zaštite:
superoksid dismutaza, katalaza i redukovani glutation.Rezultati. Kod netreniranih životinja, zapažen je negativan uticaj akutne, hronične i
direktne primene EP-a na funkciju srca. Kod treniranih životinja, akutna i hronična
konzumacija EP-a imala je za posledicu povećanje koronarnog protoka i većine
kardiodinamskih parametara, dok je direktna administracija EP-a uticala na smanjenje
stope kontraktilnosti i relaksacije, odnosno bila je povezana sa depresijom srčane
funkcije. Kod netreniranih životinja, primena EP-a ostvarila je prooksidativni uticaj
u koronarnom efluentu (akutna i direktna primena), kao i u krvi (akutna i hronična
primena). Kod treniranih životinja, akutna, hronična i direktna primena EP-a ispoljili
su prooksidativni potencijal u koronarnom efluentu, dok je u krvi nakon akutne primene
EP-a zapažen antioksidativni uticaj.
Zaključak. Naša studija doprinosi saznanjima o efektima EP-a na kardiodinamiku i
redoks status u korelaciji sa trenažnim statusom.
Authors Key words
energetska pića, kardiovaskularni sistem,
oksidativni stres, pacovi, plivanje
Authors Key words
energy drinks, cardiovascular system, oxidative stress, rats,
swimming
Classification
616.12:613.292(043.3)
Subject
Kardiovaskularni sistem - Energetska pića
Type
Tekst
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