Title
Biomarkeri inflamacije u ishemijskoj bolesti srca
Creator
Pavlović, Senada D. 1978-
Copyright date
2012
Object Links
Language
Serbian
Cobiss-ID
Inventory ID
D-2519
Theses Type
PhD thesis
description
datum odbrane: 14.11.2012.
Other responsibilities
mentor
Đorđević, Vidosava B. (ths)
član komisije
Đukić, Aleksandar, 1967- (oth, code: 07132)
član komisije
Živančević-Simonović, Snežana, 1960- (oth, code: 07138)
član komisije
Koraćević, Goran. (oth)
Academic Expertise
Medicinske nauke
University
Univerzitet u Kragujevcu
Faculty
Fakultet medicinskih nauka
Alternative title
Biomarkers Of Inflammation In Ischemic Heart Disease
Publisher
Крагујевац : [С. Д. Павловић],
Format
PDF/A (listova)
description
Umnoženo za odbranu.
MEDICINSKI FAKULTET, Univerzitet u Kragujevcu., 2012, dr medicinskih nauka, Kardiologija.
Bibliografija : listovi 114-160.
Izvod ; Abstract.
Abstract (en)
Background: Ishemic heart disease is mostly a consequence of atherosclerosis.
Atherosclerosis, a chronic inflammatory disease, underlies the pathogenesis of coronary artery disease. The present study assessed the diagnostic and prognostic validity of inflammatory biomarkers, including high sensitive C-reactive protein (hsCRP),fibrinogen, ESR, leukocytes, serum neopterin, nitrite/nitrate (NO2
–/NO3–), inducible nitricoxide synthase (iNOS), tumor necrosis factor-α (TNF-α) and asymmetric dimethylarginine (ADMA) and their correlation with risk factors in patients with acute coronary syndrome and stable angina pectoris.
Methods: We studied 74 patients with chronic stable angina pectoris, 73 with unstable angina, 94 with acute myocardial infarction and 66 age-matched healthy volunteers (control group). Serum neopterin, ADMA, iNOS and TNF-α were determined by the commercially available enzyme linked immunosorbent assay methods and NO2
– /NO3– by the modified cadmium-reduction method. The diagnostic accuracy of markers was evaluated by the ROC curve analysis.
Results: Mean serum neopterin levels were significantly higher in patients with unstable and stable angina pectoris in comparison to control subjects (p<0.05, for both patients groups). Serum NO2-/NO3– values were significantly elevated (p<0.01) in patients with unstable angina and acute myocardial infarction. Serum iNOS were significantly elevated in patients with unstable angina pectoris in comparison to control subjects (p<0.05). TNF- α was significantly elevated in patients with acute myocardial infarction in comparison to
patients with stable angina pectoris (p<0.001) and the control group (p<0.01). Serum ADMA values were significantly elevated (p<0.001) in all patient groups. The highest concentration of hsCRP, fibrinogen and leukocytes were noted in patients with acute myocardial infarction, while ESR was significantly higher in patients with unstable angina pectoris. A strong correlation was found between LE and smoking (p<0.05), and triglycerides and ESR (p<0.05), neopterin and physically inactivity (p<0.05), NO2–/NO3–and both DM (p<0.01) and physically inactivity (p<0.05) in stable angina pectoris patients. In unstable angina pectoris patients a significant correlation was found between smoking and hsCRP (p<0.05), familly history and both fibrinogen (p<0.05) and LE
(p<0.05), neopterin and concentration of lipids (p<0.05), obesity and NO2
–/NO3– (p<0.05).
Also significant correlation was found between DM and both LE (p<0.05) and hsCRP
(p<0.01), ADMA and both DM (p<0.05) and smoking (p<0.05) in patients with acute
myocardial infarction.
Conclusion: The results of this study suggest that elevated baseline levels of ADMA are a strong and independent predictor of ischemic heart disease. Continuous monitoring of serum neopterin and NO2–/NO3– levels may indicate future plaque instability.
Interdependence between inflammatory markers and cardiovascular risk factors was
established.
Authors Key words
markeri inflamacije, ateroskelroza ishemijska bolest srca
Authors Key words
markeri inflamacije
Classification
616
Type
monograph
manuscript text - theses
Text
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